Prognostic significance of aqueous humour lactic dehydrogenase activity.

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Prognostic significance of aqueous humour lactic dehydrogenase activity.

The lactic dehydrogenase (LDH) activity of the aqueous humour has been estimated in both eyes of 7 patients having uniocular retinoblastoma. In 1 patient the aqueous humour LDH activity in the healthy eye was above normal, but there was no clinical evidence of malignancy. Tumour tissue was detected in this eye 9 months later, and the aqueous humour showed a rise in LDH activity. A high LDH acti...

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Lactic dehydrogenase activity of aqueous humour in retinoblastoma.

Although the levels of LDH have been estimated in the aqueous humour of animals (Kuhlman, and Kaufman, I960), information regarding LDH levels in human aqueous humour appears to be scanty. It is known that malignant tumours at different sites in the body are associated with an increased LDH activity in the corresponding body fluid (Wroblewski, 1957). The purpose of the present study is to deter...

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Aqueous humour lactic dehydrogenase isoenzymes in retinoblastoma.

LDH activity was determined in aqueous humour samples from 11 eyes (of 10 children), four of which contained retinoblastoma. Simultaneous serum LDH levels were also determined in eight of the children. There was no correlation between serum and aqueous humour LDH activity. Total aqueous humour LDH activity ranged from 0 to 99 i.u/l. in the seven eyes with non-neoplastic conditions. It was 56, 1...

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Correlation of aqueous humour lactic acid dehydrogenase activity with intraocular pathology.

An analysis of the lactic acid dehydrogenase (LDH) activity in the aqueous humour of 24 enucleated eyes with retinoblastoma showed that though there was no relationship between the LDH levels and the age of the patient, there appeared to be an increase in the LDH activity with increase in the duration of the tumour. Undifferentiated tumour cells and tumour cell necrosis seemed to contribute to ...

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Lactate dehydrogenase and oxidative stress activity in primary open-angle glaucoma aqueous humour.

Lactate dehydrogenase (LDH) and lactate are some of the hypoxy biochemical parameters. Extracellular activity of this enzyme increases under the condition of oxidative stress, since the cell integrity can be disrupted during the lipid peroxidation process. Subsequently that leads to the increase level of the lactic acid and lactic acid salts. The objective of this investigation is establishing ...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1979

ISSN: 0007-1161

DOI: 10.1136/bjo.63.8.571